Autonomic cardiac innervation

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Autonomic cardiac innervation

Autonomic cardiac neurons have a common origin in the neural crest but undergo distinct developmental differentiation as they mature toward their adult phenotype. Progenitor cells respond to repulsive cues during migration, followed by differentiation cues from paracrine sources that promote neurochemistry and differentiation. When autonomic axons start to innervate cardiac tissue, neurotrophic...

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Ischemic modulation of cardiac autonomic innervation.

Numerous studies in experimental animals have established the importance of the autonomic nervous system in the genesis of a wide variety of cardiac arrhythmias. The most compelling clinical data supporting the role of sympathetic innervation in ischemia-related arrhythmias come from the studies demonstrating a reduction in total and sudden cardiac death in patients treated with a beta-adrenoce...

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Autonomic Innervation of Heart

T he vagus and sympathetic nerves link the heart to the central nervous system, carrying information from the heart over neural afferents and to the heart over neural efferents. Although it is generally well accepted that the autonomic nervous system can promote, precipitate, or prevent the development of cardiac arrhythmias, the mechanisms by which this transpires are incompletely understood. ...

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Autonomic innervation of the heart.

This brief review describes recent advances in the areas of myocardial receptors that discharge into nonmyelinated, afferent, vagal C-fibers and the regional distribution of sympathetic postganglionic neurons to the myocardium. Complex, nonencapsulated nerve endings discharging into myelinated afferents have been known to exist for many years. More recently, however, indirect evidence for the e...

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Effect of Digoxin on Atrioventricular Conduction Studies in Patients with and without Cardiac Autonomic Innervation

The effect of digoxin on atrioventricular (A-V) conduction-was compared in five patients with an intact cardiac autonomic nervous system (Group I) and seven patients who had undergone cardiac transplantation (Group II), in whom we have previously shown the transplanted heart to be completely denervated.Small decreases in the atrial effective refractory period (ERP) (from 262 ± 12 to 254 ± 11 ms...

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ژورنال

عنوان ژورنال: Organogenesis

سال: 2013

ISSN: 1547-6278,1555-8592

DOI: 10.4161/org.24892